Treatment-Resistant Depression
When nothing else has worked, a different path may be possible.
If you’ve tried multiple medications, therapies, or approaches and are still struggling, you’re not alone. Treatment-resistant depression can feel discouraging, exhausting, and at times, hopeless.
At Reunion Psychedelic Therapy, we offer a different model, one that combines evidence-based psychotherapy with carefully guided psychedelic-assisted treatments to help unlock meaningful change where other approaches have fallen short.
What is Treatment-Resistant Depression?
Treatment-resistant depression (TRD) is typically defined as depression that has not improved after trying at least two standard treatments, such as antidepressant medications or traditional therapy.
For many, this can feel like being stuck, wanting relief, but not knowing where to turn next.
A New Approach: Psychedelic-Assisted Psychotherapy
Rather than only managing symptoms, our approach focuses on creating the conditions for deeper psychological and neurological change.
We offer a structured, three-phase process:
Preparation – Comprehensive assessment, intention-setting, and psychological readiness
Facilitated Experience – Carefully monitored sessions in a safe, supportive environment
Integration – Ongoing therapy to help translate insights into lasting change
Psychedelic-Assisted Psychotherapy (PAP)
A breakthrough option for treatment-resistant depression
Reunion offers one of the most well-established psychedelic-assisted treatments for depression and has been widely studied for its rapid antidepressant effects.
What sets psychedelic-assisted psychotherapy apart:
Rapid relief – Many patients experience improvement within hours to days
Works differently than antidepressants – Targets glutamate and supports neuroplasticity
Interrupts rigid thought patterns – Can help “reset” entrenched depressive loops
Enhances therapy – Creates a window for deeper emotional processing and insight
At Reunion, psychedelic medicines are always paired with psychotherapy and delivered in a carefully supported environment by trained clinicians. Our focus is not just symptom relief, but meaningful, sustained transformation.
Why Reunion?
Psychotherapy-first model – Treatment is grounded in deep therapeutic work, not just medication
Experienced multidisciplinary team – Licensed psychologists and nurses trained in working with expanded states of consciousness
Evidence-informed care – Integrating approaches such as EMDR and trauma-focused therapies
Supportive, non-clinical environment – Designed to feel safe, comfortable, and human
Group and individual options – Increasing access while maintaining high-quality care
Is This Right for You?
You may be a good candidate if:
You have tried multiple treatments without sufficient relief
You feel stuck in persistent patterns of depression
You are open to a deeper, experiential approach to healing
You are medically and psychiatrically appropriate for treatment