Treatment-Resistant Depression
When nothing else has worked, a different path may be possible.
If you’ve tried multiple medications, therapies, or approaches and are still struggling, you’re not alone. Treatment-resistant depression can feel discouraging, exhausting, and at times, hopeless.
At Reunion Psychedelic Therapy, we offer a different model, one that combines evidence-based psychotherapy with carefully guided psychedelic-assisted treatments to help unlock meaningful change where other approaches have fallen short.
What is Treatment-Resistant Depression?
Treatment-resistant depression (TRD) is typically defined as depression that has not improved after trying at least two standard treatments, such as antidepressant medications or traditional therapy.
For many, this can feel like being stuck, wanting relief, but not knowing where to turn next.
A New Approach: Psychedelic-Assisted Psychotherapy
Rather than only managing symptoms, our approach focuses on creating the conditions for deeper psychological and neurological change.
We offer a structured, three-phase process:
Preparation – Comprehensive assessment, intention-setting, and psychological readiness
Facilitated Experience – Carefully monitored sessions in a safe, supportive environment
Integration – Ongoing therapy to help translate insights into lasting change
Ketamine-Assisted Psychotherapy (KAP)
A breakthrough option for treatment-resistant depression
Ketamine is one of the most well-established psychedelic-assisted treatments for depression and has been widely studied for its rapid antidepressant effects.
What makes ketamine different:
Rapid relief – Many patients experience improvement within hours to days
Works differently than antidepressants – Targets glutamate and supports neuroplasticity
Interrupts rigid thought patterns – Can help “reset” entrenched depressive loops
Enhances therapy – Creates a window for deeper emotional processing and insight
At Reunion, ketamine is always paired with psychotherapy and delivered in a carefully supported environment by trained clinicians. Our focus is not just symptom relief, but meaningful, sustained transformation.
Psilocybin-Assisted Psychotherapy
Available through Health Canada’s Special Access Program
Psilocybin (the active compound in “magic mushrooms”) is emerging as one of the most promising treatments for depression, particularly for individuals who have not responded to conventional care.
At Reunion, psilocybin-assisted psychotherapy may be accessed through Health Canada’s Special Access Program (SAP), following medical and psychiatric screening.
Why psilocybin shows promise:
DeepDeep, meaningful experiences that can shift perspective and emotional patterns
Reduced activity in rigid brain networks (such as the default mode network)
Increased emotional openness and connection
Potential for lasting improvement after limited sessions
This approach is carefully guided, with a strong emphasis on preparation and integration to support safety and long-term benefit.
Why Reunion?
Psychotherapy-first model – Treatment is grounded in deep therapeutic work, not just medication
Experienced multidisciplinary team – Licensed psychologists and nurses trained in working with expanded states of consciousness
Evidence-informed care – Integrating approaches such as EMDR and trauma-focused therapies
Supportive, non-clinical environment – Designed to feel safe, comfortable, and human
Group and individual options – Increasing access while maintaining high-quality care
Since its inception, Reunion has been providing ketamine-assisted psychotherapy, as well as psilocybin and MDMA-assisted psychotherapy through Health Canada’s Special Access Program.
Is This Right for You?
You may be a good candidate if:
You have tried multiple treatments without sufficient relief
You feel stuck in persistent patterns of depression
You are open to a deeper, experiential approach to healing
You are medically and psychiatrically appropriate for treatment
Take the Next Step
You don’t have to stay stuck.
If you’re curious about whether this approach may be right for you, we invite you to begin with a consultation.